We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Read More
9
Vitamin C helps rheumatoid arthritis
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance.
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Read More
8
Vitamin C may lower hypothyroidism risk
Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012.
We aimed to understand how vitamin C intake influences hypothyroidism in patients with Hashimoto thyroiditis (HT). Through a detailed analysis of data collected in the National Health and Nutrition Examination Survey from 2007 to 2012, we found notable results that shed light on this relationship.
Our study involved looking at various participants categorized by their total vitamin C intake. We discovered a significant negative correlation between the amount of vitamin C consumed and the likelihood of developing hypothyroidism in those with HT. In essence, individuals drinking higher amounts of vitamin C—up to 1,258.9 mg per day—exhibited a lower probability of experiencing hypothyroidism compared to those with minimal intake.
Furthermore, this connection remained apparent even when we examined different age groups and genders, indicating that vitamin C could play a protective role against hypothyroidism related to Hashimoto's thyroiditis. Thus, our findings suggest that enhancing vitamin C consumption might be a beneficial strategy for those managing this autoimmune condition.
Read More
Most Useful Reviews
9
Trustworthy immune support
8 people found this helpful
Vitamin C + Quercetin supports immunity! I'm confident in this brand, having used many of their products. The 250-capsule packaging lasts long. This combination, a strong antioxidant, is invaluable and family-friendly. They are easy to swallow, and I’ve noticed significant immunity support during illness. I will keep ordering!
Read More
10
Non-allergenic support
1 people found this helpful
I ordered this excellent vitamin for my child; it doesn’t cause allergies. Half a pill is effective! It’s helped in combating viruses; since we began taking it, we've stopped falling ill frequently.
Read More
9
Quick illness recovery
1 people found this helpful
Previously, I bought a large bottle and loved it. During my recent illness, I took 2 tablets 4-5 times daily and recovered in just a day compared to lasting a week before. I will definitely order more.
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Read More
9
Vitamin C aids rheumatoid arthritis treatment
A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis.
This study investigated the effects of a specially formulated hydrogel that combines vitamin C with 9-aminoacridine (9AA) on a model of rheumatoid arthritis (RA). We saw that this hydrogel is not only bioactive but also biodegradable, making it a potential candidate for treating this chronic autoimmune condition.
Our research showed that the combination of vitamin C—specifically in the form of 6-stearoyl-L-ascorbic acid—and 9AA could significantly reduce inflammation in our experimental model. By acting on specific pathways, such as the NR4A1 nuclear receptor, the hydrogel appears to exert anti-inflammatory effects that could alleviate some symptoms of arthritis.
We also noted that vitamin C plays a dual role by promoting collagen production, which is essential for joint health. This is crucial since RA leads to the deterioration of joint tissues.
In conclusion, our findings suggest that using this hydrogel could represent a more effective treatment strategy for RA compared to existing options. With its ability to reduce inflammation and promote tissue healing, this innovative approach offers hope to those suffering from this debilitating condition.
Read More
9
Vitamin C helps rheumatoid arthritis
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance.
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Read More
9
Ascorbyl palmitate targets inflammation
Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome.
We examined the effects of ascorbyl palmitate (AP), a derivative of vitamin C, on the NLRP3 inflammasome, which plays a significant role in various autoimmune disorders. The research shows that AP effectively inhibits the activation of this inflammasome, suggesting it could be a powerful tool in managing inflammation-driven diseases.
Notably, AP showed greater potency and specificity in inhibiting the inflammasome compared to regular vitamin C. It appears to achieve this by scavenging harmful reactive oxygen species and disrupting key interactions necessary for inflammasome assembly.
Furthermore, we found that AP exhibited more pronounced protective effects in models of systemic inflammation and conditions like colitis and autoimmune encephalomyelitis than standard vitamin C treatments. This strengthens the case that AP could be a viable therapeutic option for combating NLRP3-driven diseases, presenting an exciting avenue for further research and potential clinical applications.
Read More
9
Vitamin C's Role in Inflammation
Rheumatologic manifestations with elevated levels of IL-6, IL-17A, and IL-23 in a patient with scurvy.
We observed a fascinating case involving an 11-year-old boy suffering from symptoms of scurvy, a condition arising from severe vitamin C deficiency. This boy had multiple issues, including iron-deficiency anemia, symptoms resembling bone infections, and muscle inflammation, particularly in his legs. His selective diet, likely due to a mild developmental disorder, led to a significant deficiency in vitamin C.
After he was diagnosed, we administered intravenous and oral vitamin C, which remarkably eased his joint and muscle pain within just a week. Following four months of supplementation, he showed complete recovery with no lingering symptoms or abnormal lab findings.
Notably, we found high levels of certain pro-inflammatory markers, specifically interleukin-6, IL-17A, and IL-23, likely linked to an immune response involving T-helper 17 cells. This association presents an intriguing insight into the inflammatory processes that might be involved in scurvy and, potentially, in other autoimmune disorders.
Our observations hint that vitamin C might play a pivotal role in addressing inflammation linked to autoimmune conditions, paving the way for enhanced understanding and treatment options in the future.
Vitamin C + Quercetin supports immunity! I'm confident in this brand, having used many of their products. The 250-capsule packaging lasts long. This combination, a strong antioxidant, is invaluable and family-friendly. They are easy to swallow, and I’ve noticed significant immunity support during illness. I will keep ordering!
Read More
10
Non-allergenic support
1 people found this helpful
I ordered this excellent vitamin for my child; it doesn’t cause allergies. Half a pill is effective! It’s helped in combating viruses; since we began taking it, we've stopped falling ill frequently.
Read More
9
Quick illness recovery
1 people found this helpful
Previously, I bought a large bottle and loved it. During my recent illness, I took 2 tablets 4-5 times daily and recovered in just a day compared to lasting a week before. I will definitely order more.
Read More
9
Family immune boost
1 people found this helpful
My favourite vitamin combination is C and quercetin; they work excellently together. The ingredients' quality is outstanding. I've noticed a significant improvement in inflammation and uric acid levels from the first capsule. I will keep ordering this for my family, especially during illness.
Read More
7.5
Post-Covid support
On my doctor’s advice, I ordered vitamin C with bioquercetin, which has greatly improved my immunity after recovering from Covid.
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays a critical role in numerous bodily functions. As an essential nutrient, it contributes to the growth and repair of tissues in the body, and it is vital for the production of collagen, an important protein that helps maintain skin, cartilage, tendons, ligaments, and blood vessels. Additionally, Vitamin C acts as a powerful antioxidant, which means it helps combat free radicals—unstable molecules that can cause oxidative stress and contribute to various chronic diseases.
Moreover, Vitamin C enhances iron absorption from plant-based foods, making it a vital component for those following vegetarian or vegan diets. While many people get sufficient Vitamin C from a well-balanced diet that includes fruits and vegetables like oranges, strawberries, kiwi, broccoli, and bell peppers, some individuals might require supplementation. It's generally recommended to stay within the daily intake guidelines, as excessive consumption can lead to gastrointestinal disturbances. Overall, Vitamin C is not just a skincare celebrity—it's a fundamental part of maintaining overall health and well-being.
Based on user reviews, the timeline for seeing results from this Vitamin C and quercetin supplement can vary, with some users reporting significant improvements shortly after starting the regimen. For example, one user noted that they observed a remarkable enhancement in inflammation and other health markers from the very first capsule (Read Review). Additionally, another reviewer experienced a rapid recovery from illness, saying it helped them bounce back in just one day compared to previous illnesses that lasted much longer (Read Review).
However, while immediate benefits can occur, some may see a more gradual improvement over time. For users managing autoimmune disorders, consistent use appears to provide cumulative effects, as indicated by one reviewer who noted that the product significantly aided in managing their condition and had ordered it multiple times (Read Review). Overall, while some may notice results within days, others might take longer to feel the full benefits of the supplement.
Vitamin C has garnered attention for its potential benefits in managing autoimmune disorders, supported by a growing body of scientific research. One study indicated that high vitamin C intake is correlated with a lower incidence of hypothyroidism in individuals with Hashimoto's thyroiditis, implying a protective role for this vitamin in autoimmune conditions [2]. Additionally, various studies demonstrate vitamin C’s effectiveness in reducing inflammation and modifying immune responses in conditions such as rheumatoid arthritis. For instance, vitamin C administration in murine models led to delayed arthritis onset and reduced disease severity, suggesting its potential as a strategic tool in autoimmune management [3].
Moreover, innovative approaches incorporating vitamin C into treatment protocols have shown promise. A hydrogel formulation combining vitamin C with other compounds displayed significant anti-inflammatory effects in rheumatoid arthritis models [5]. However, while these findings highlight vitamin C's potential, they underline the necessity for more clinical research to fully elucidate its effectiveness and mechanisms in various autoimmune disorders. The existing evidence suggests that vitamin C may serve as a valuable complement in treatment strategies, although further studies are essential to confirm its comprehensive role in managing autoimmune diseases.
Users have reported considerable improvements in various health symptoms after taking the Vitamin C and quercetin supplement. A common theme among reviews is enhanced immunity; one user noted significant support during illness, allowing them to recover quickly thanks to this product (Read Review). Another user highlighted a marked increase in resistance to viruses, claiming that since starting the supplement, their family has stopped falling ill frequently (Read Review).
Additionally, several users dealing with specific health issues have praised the supplement's efficacy. For instance, a reviewer stated they recovered from an illness in just a day, a notable improvement compared to prior experiences when recovery would take a week (Read Review). Another customer, who used it post-Covid, observed a significant boost in immunity and overall recovery from lingering issues (Read Review). While individual results can vary, many users emphasize the positive impact on their health and well-being from consistent use of this supplement.
Users have generally reported positive experiences when combining this Vitamin C and quercetin supplement with other supplements for managing autoimmune disorders. One user specifically noted that this product significantly aids in controlling their autoimmune condition, indicating its effectiveness as part of a broader health regimen (Read Review). Another user highlighted the benefits of including bioflavonoids alongside Vitamin C, suggesting that the synergy within these combinations may enhance recovery and support for the immune system, particularly for those with sensitive health issues (Read Review).
Moreover, a reviewer who utilized the Vitamin C formula post-Covid under their doctor's advice confirmed a significant improvement in immunity, illustrating how this supplement can be effectively integrated into a recovery plan from autoimmune-related concerns (Read Review). Overall, the testimonials suggest that users appreciate the potential benefits of combining this product with other supplements, leading to enhanced health outcomes for those dealing with autoimmune disorders.
Users report a variety of doses for Vitamin C when treating autoimmune disorders, with many finding significant benefits. One user noted that for acute illness recovery, taking 2 tablets 4-5 times daily led to a rapid recovery compared to previous experiences, suggesting a higher intake can be effective during illness Read Review. Others have mentioned using specific formulations containing 1000 mg of Vitamin C along with bioquercetin, highlighting improved absorption and overall health benefits, particularly after viral infections Read Review.
Several reviews indicate that combining Vitamin C with other ingredients, like quercetin and bioflavonoids, seems to enhance its effectiveness against inflammation and provide additional immunity support Read ReviewRead Review. While individual responses to dosage may vary, there is a consensus among users that higher doses during illness contribute positively to recovery and management of autoimmune disorders Read Review.
9
Family immune boost
1 people found this helpful
My favourite vitamin combination is C and quercetin; they work excellently together. The ingredients' quality is outstanding. I've noticed a significant improvement in inflammation and uric acid levels from the first capsule. I will keep ordering this for my family, especially during illness.
9
Quick illness recovery
1 people found this helpful
Previously, I bought a large bottle and loved it. During my recent illness, I took 2 tablets 4-5 times daily and recovered in just a day compared to lasting a week before. I will definitely order more.
8
Quality product
It’s not my first order of this product; I have purchased it multiple times. The quality is outstanding. It contains various ingredients, and the size is excellent. The smell is pleasant, and I find the price reasonable. This product significantly aids in managing my autoimmune disorder.
9
Trustworthy immune support
8 people found this helpful
Vitamin C + Quercetin supports immunity! I'm confident in this brand, having used many of their products. The 250-capsule packaging lasts long. This combination, a strong antioxidant, is invaluable and family-friendly. They are easy to swallow, and I’ve noticed significant immunity support during illness. I will keep ordering!
10
Non-allergenic support
1 people found this helpful
I ordered this excellent vitamin for my child; it doesn’t cause allergies. Half a pill is effective! It’s helped in combating viruses; since we began taking it, we've stopped falling ill frequently.
7.5
Post-Covid support
On my doctor’s advice, I ordered vitamin C with bioquercetin, which has greatly improved my immunity after recovering from Covid.
6
Enhanced recovery speed
5 people found this helpful
The large jar I ordered is fantastic! It contains bioflavonoids, which helped my mother recover quickly from illness. I have always prioritised flavonoids alongside vitamin C, and this combination works wonders for my fragile capillaries, preventing bruising.
7.5
Supports recovery efforts
86 people found this helpful
I greatly value Life Extension products, especially during the 2020 pandemic. This vitamin C formula, with a dosage of 1000 mg as ascorbic acid, is effective and includes bio-quercetin phytosomes, which enhance absorption. Following my Covid illness, I faced prolonged weakness and heart issues. This vitamin C helped in my recovery, as quercetin boosts absorption of vitamin C and zinc, reducing chronic vascular disease risk. My body responds well to this formula; it's a worthwhile investment for my health.
8
Vitamin C may lower hypothyroidism risk
Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012.
We aimed to understand how vitamin C intake influences hypothyroidism in patients with Hashimoto thyroiditis (HT). Through a detailed analysis of data collected in the National Health and Nutrition Examination Survey from 2007 to 2012, we found notable results that shed light on this relationship.
Our study involved looking at various participants categorized by their total vitamin C intake. We discovered a significant negative correlation between the amount of vitamin C consumed and the likelihood of developing hypothyroidism in those with HT. In essence, individuals drinking higher amounts of vitamin C—up to 1,258.9 mg per day—exhibited a lower probability of experiencing hypothyroidism compared to those with minimal intake.
Furthermore, this connection remained apparent even when we examined different age groups and genders, indicating that vitamin C could play a protective role against hypothyroidism related to Hashimoto's thyroiditis. Thus, our findings suggest that enhancing vitamin C consumption might be a beneficial strategy for those managing this autoimmune condition.
9
Vitamin C impacts autoimmune response
Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies.
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
9
Vitamin C aids rheumatoid arthritis treatment
A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis.
This study investigated the effects of a specially formulated hydrogel that combines vitamin C with 9-aminoacridine (9AA) on a model of rheumatoid arthritis (RA). We saw that this hydrogel is not only bioactive but also biodegradable, making it a potential candidate for treating this chronic autoimmune condition.
Our research showed that the combination of vitamin C—specifically in the form of 6-stearoyl-L-ascorbic acid—and 9AA could significantly reduce inflammation in our experimental model. By acting on specific pathways, such as the NR4A1 nuclear receptor, the hydrogel appears to exert anti-inflammatory effects that could alleviate some symptoms of arthritis.
We also noted that vitamin C plays a dual role by promoting collagen production, which is essential for joint health. This is crucial since RA leads to the deterioration of joint tissues.
In conclusion, our findings suggest that using this hydrogel could represent a more effective treatment strategy for RA compared to existing options. With its ability to reduce inflammation and promote tissue healing, this innovative approach offers hope to those suffering from this debilitating condition.
References
Zhang H, Zhang Y, Zhang Y, Wei H, Jin S, et al. Combination of inorganic nitrate and vitamin C prevents collagen-induced arthritis in rats by inhibiting pyroptosis. Food Funct. 2025;16:673. 10.1039/d4fo03096f
Chen L, Mao Y, Chen G. Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012. Br J Nutr. 2024;132:1575. 10.1017/S0007114524001715
Yin Y, Wu S. Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies. Cell Commun Signal. 2024;22:373. 10.1186/s12964-024-01756-x
Isola S, Gammeri L, Furci F, Gangemi S, Pioggia G, et al. Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy. Int J Mol Sci. 2024;25. 10.3390/ijms25137284
Ali A, Jori C, Kumar A, Vyawahare A, Kumar J, et al. A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis. Biomater Sci. 2024;12:3389. 10.1039/d4bm00243a
Zhang Y, Zhen S, Xu H, Sun S, Wang Z, et al. Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance. Biosci Trends. 2024;18:187. 10.5582/bst.2024.01037
Zhang L, Li G, Lin B, He H, Zhou R, et al. Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome. Int Immunopharmacol. 2024;131:111915. 10.1016/j.intimp.2024.111915
Santiworakul C, Saisorn W, Siripen N, Leelahavanichkul A, Rianthavorn P. Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency. Pediatr Nephrol. 2024;39:1135. 10.1007/s00467-023-06189-1
Mungan S, Guzel I, Demirdogen BC. Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis. Braz J Med Biol Res. 2023;56:e12776. 10.1590/1414-431X2023e12776
Farasati Far B, Behnoush AH, Ghondaghsaz E, Habibi MA, Khalaji A. The interplay between vitamin C and thyroid. Endocrinol Diabetes Metab. 2023;6:e432. 10.1002/edm2.432
Ueki M, Sakamoto K, Nishioka N, Ohata H, Nobuta T, et al. Rheumatologic manifestations with elevated levels of IL-6, IL-17A, and IL-23 in a patient with scurvy. Mod Rheumatol Case Rep. 2023;7:302. 10.1093/mrcr/rxac059